Response of myocardial connective tissue to development of experimental hypertrophy.

BUCCINO, R. A., E. HARRIS, J. F. SPANN, JR., AND E. H. SONNENBLICK. Response of myocardial connective tissue to development of experimental hypertrophy.. Am. J. Physiol. 2 16(2) : 425-428. 1969.-Myocardial collagen concentration was determined by measuring hydroxyproline in right and left ventricles of normal. cats and those with right ventricular hypertrophy produced by chronic constriction of the pulmonary artery. Both in normal and hypertrophied ventricles, hydroxyproline concentration was significantly higher in the epimyocardium than in endomyocardium; and in both the epimyocardium and endomyocardium, hydroxyproline was significantly higher in right ventricular than in corresponding left ventricular specimens. In the presence of right ventricular hypertrophy, the concentration, as well as the total content of hydroxyproline, increased in both the right and the unstressed left ventricle.